Thrombocytopenic Purpura

Definition Thrombocytopenic purpura is a hematological disorder characterized by a decrease in platelets in the peripheral blood.
Etiology Presumably a nonspecific viral infection, myelotoxic agents.
Clinical features The oral manifestations consist of red lesions in the form of petechiae, ecchymoses, or even hematomas, usually located on the palate and buccal mucosa. Spontaneous gingival bleeding is a constant early finding. Purpuric skin rash, epistaxis, and bleeding from the gastrointestinal and urinary tract are common.
Laboratory tests Peripheral platelet count, bone-marrow aspiration, bleeding and clotting times.
Differential diagnosis Aplastic anemia, leukemias, polycythemia vera, agranulocytosis, macroglobulinemia, drug reactions.
Treatment Steroids, platelet transfusions, cessation of drug treatment if it is drug-related.
Idiopathic thrombocytopenic purpura: petechiae and ecchymoses of the buccal mucosa

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