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For Appointment with our Doctors.... Call : 8125360807, 8885548487 ....Email: krishna_p91@yahoo.com

Welcome to Shree Sai Dental hospital.( Nallakunta / Shankarmatt.)

The new millennium has begun with the century of globalization. At Shree Sai Dental Clinic, we are changing the way people feel about the revolutionary developments of dentistry. We pride ourselves on delivering dental services to our patients which are matching with international standards. The interest and excitement surrounding esthetic dentistry has added a new dimension to our hub. New widespread public awareness has created a demand for superior esthetic results and is a primary motivating factor for patients seeking dental care.

It is no longer possible for a single specialist to handle the esthetic and functional demands of the patients and interdisciplinary approach has gained wide acceptance. Our practice is committed to provide comprehensive dental care with an emphasis on smile restoration employing the latest cosmetic dentistry procedures including dental implants, porcelain veneers, porcelain crowns and bridges, teeth whitening and composite white fillings. Whether you are looking to subtly enhance your smile or are in need of more extensive dental work, contact us today and we will be glad to help. We rediscover Ur Smile!

Our dental practice offers a full range of first class dental services, from Cosmetic Dentistry procedures including porcelain veneers, porcelain crowns, correction of irregular and crooked teeth (braces – metallic/ceramic), bonding and teeth whitening, to restorative procedures such as dental implants and bridges. We specialize in full mouth restorations employing the latest technology and techniques available to give our patients outstanding results.

We have made dental care more convenient by providing high quality cosmetic dental treatments at fees that are easy on the pocket. We welcome you to experience the satisfaction, growth and professional status that our center has to offer and look forward to meeting you!

Please feel free to navigate the site and contact us personally for any queries. Or better yet, stop in to meet us!


PH: 8125360807, 8885548487

DNA Vaccines Show Promise in Preventing Dental Caries

DNA Vaccines Show Promise in Preventing Dental Caries



 In a report on a preclinical investigation titled "Flagellin Enhances Saliva Ig A Response and Protection of Anti-caries DNA Vaccine," lead author Wei Shi, Wuhan Institute of Virology, Chinese Academy of Sciences, and his team of researchers demonstrate that anti-caries DNA vaccines, including pGJA-P/VAX, are promising for preventing dental caries. However, challenges remain because of the low immunogenicity of DNA vaccines.

In this study, Shi and team used recombinant flagellin protein derived from Salmonella as mucosal adjuvant for anti-caries DNA vaccine (pGJA-P/VAX) and analyzed the effects of Salmonella protein on the serum surface protein immunoglobulin G and saliva surface protein immunoglobulin A antibody responses, the colonization of Streptococcus mutans (S. mutans) on rodent teeth, and the formation of caries lesions. The results showed that Salmonella promoted the production of surface protein immunoglobulin G in serum and secretory immunoglobulin A in saliva of animals by intranasal immunization with pGJA-P/VAX plus Salmonella.This study is published in the Journal of Dental Research, the official publication of the International and American Associations for Dental Research (IADR/AADR).
Furthermore, Shi found that enhanced surface protein immunoglobulin A responses in saliva were associated with inhibition of S. mutans colonization of tooth surfaces and endowed better protection with significant less carious lesions. In conclusion, the study demonstrates that recombinant Salmonella could enhance specific immunoglobulin A responses in saliva and protective ability of pGJA-P/VAX, providing an effective mucosal adjuvant candidate for intranasal immunization of an anti-caries DNA vaccine.
Daniel Smith, The Forsyth Institute, wrote a corresponding perspective article in response to the Shi et al report titled "Prospects in Caries Vaccine Development." In it, he states that DNA vaccine approaches for dental caries have had a history of success in animal models. Dental caries vaccines, directed to key components of S. mutans colonization and enhanced by safe and effective adjuvants and optimal delivery vehicles, are likely to be forthcoming

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